Causes

What are risk factors for anal cancer? Anal cancer can occur in any person, but some people have a higher risk of developing it than others. Risk factors include: Human papilloma virus infection (HPV): HPV is a group of viruses that are sexually transmitted and remain in the body after infection. HPV is present in most cases of anal cancer. It was also the leading cause of cervical cancer before the introduction of routine Pap smears. Human immunodeficiency virus (HIV): HIV, the precursor to AIDS, puts people at a higher risk of anal cancer, because it compromises your immune system. Sexual activity: Having multiple sex partners and having receptive anal sex can increase your risk of getting anal cancer. Not wearing barrier protection, like condoms, also increases the risk of anal cancer due to increased risk of contracting HPV. Smoking: Smokers are more likely to develop cancer of the anus, even if they quit smoking. Weak immune systems: This can leave your body defenseless against anal cancer and is most common in people with HIV and people who take immunosuppressants or who have had an organ transplant. Old age: Most cases of anal cancer occur in people over the age of 50, according to the Mayo Clinic. What causes anal cancer? Anal cancer is caused by the development of abnormal cells in the body. These abnormal cells can grow uncontrollably and accumulate, forming masses known as tumors. Cancer cells can metastasize, or spread to other parts of the body and interfere with normal functions. Anal cancer is thought to be caused in part by the human papillomavirus (HPV), a sexually transmitted disease. It’s prevalent in a majority of anal cancer cases. Anal cancer may also be caused by other cancers in the body spreading to the anal canal. In other words, cancer develops somewhere else in the body first and then metastasizes to the anus.

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Medical Author: Dr. med. Diana Hysi